Closed-Loop Deep Brain Stimulation for Major Depression (PReSiDio)

Personalized Treatment for Depression
This study will use a personalized approach to brain stimulation as an intervention for depression. This study is intended for patients with treatment-resistant major depressive disorder whose symptoms have not been adequately treated with currently available therapies.
What is Deep Brain Stimulation?
Deep brain stimulation is a surgical procedure that aims to treat neurological disorders by using electrodes to send electrical pulses to specific areas of the brain.
Learn more!
Neuropace RNS System
The RNS neurostimulator is an implanted device that records brain activity and delivers responsive electrical pulses. We utilize this device to modulate brain activity associated with depressive symptoms.
Read this article about a previous participant's experience
See if you qualify for the study!
We are currently recruiting research participants between the ages of 22-75. You must be able to receive an MRI.

For more information on eligibility read our FAQ page.
Screening survey

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Funding for the study comes the Ray and Dagmar Dolby Family Fund, the 1907 Research Trailblazer Award, the National Institute of Neurological Disorders and Stroke, National Institute on Deafness and Other Communication Disorders (NIDCD), and the Brain & Behavior Research Foundation Young Investigator Grant.

NCT04004169  
IRB# 17-23724