Joline Fan, MD, MS | The Presidio Study - Personalized Deep Brain Stimulation for Treatment Resistant Depression

Asst Professor Clin Neurology

M_Neurology

+1 415 353-2273

Joline Fan, MD, MS, is an Assistant Professor at UCSF in the Departments of Neurology (Division of Epilepsy) and Psychiatry & Behavioral Sciences. Her research focuses on developing innovative neurostimulation technologies for neuropsychiatric disorders and exploring the complex relationship between sleep and epilepsy through multimodal neuroimaging. As an epileptologist, Dr. Fan specializes in invasive recording methods, including intracranial responsive neurostimulation and stimulation mapping. She is also investigating personalized, non-invasive, low-intensity focused ultrasound methods for treating neuropsychiatric disorders like depression and epilepsy.

Publications

287. Modulation of Human Intracranial Circuit Physiology and Personalized Neural Biomarkers Associated With Symptom State in Treatment-Resistant Depression.

Biological psychiatry

Anusha Allawala, Ankit N. Khambhati, Kristin Sellers, Daniela Astudillo Maya, Alexandra Tremblay-McGaw, Noah Stapper, Ellie Kunwar, Kai Woodworth, Inhauck Choi, Joncarmen Mergenthaler, Joline Fan, Vikram Rao, Leo Sugrue, Katherine Scangos, Edward F. Chang, Andrew D. Krystal

303. Decoding Multiday Rhythms in Mood in Human Treatment-Resistant Depression.

Biological psychiatry

PS Nandini, Joline M. Fan, Kristin K. Sellers, Daniela Astudillo Maya, Alexandra Tremblay-McGaw, Natalie Becker, Anusha Allawala, Leo P. Sugrue, Vikram R. Rao, Andrew Krystal, Edward F. Chang, Ankit N. Khambhati

35. Personalized Stimulation Targets for Closed-Loop Deep Brain Stimulation for Major Depressive Disorder.

Biological psychiatry

Kristin Sellers, Daniela Astudillo Maya, Alexandra Tremblay-McGaw, Noah Stapper, Caspian Henderson, Inhauck Choi, Joncarmen Mergenthaler, Natalie Becker, Elysha Kunwar, Anusha Allawala, Elissa Hamlat, Kai Woodworth, Joline Fan, Ankit N. Khambhati, Vikram Rao, Leo Sugrue, Joshua Cohen, Katherine Scangos, Edward Chang, Andrew Krystal

Invasive Brain Mapping Identifies Personalized Therapeutic Neuromodulation Targets for Obsessive-Compulsive Disorder.

medRxiv : the preprint server for health sciences

Lee AM, Kist A, Alvarez J, Sellers KK, Khambhati AN, Sugrue LP, Reid LB, Kadlec K, Fan JM, Allawala AB, Racine CA, Norbu T, Astudillo D, Tremblay-McGaw AG, Becker N, Alhourani A, Starr PA, Chang EF, Krystal AD

Influences of electrode density on intracranial seizure localisation: a single-blinded randomised crossover study.

EBioMedicine

Chinedu-Eneh EO, Chiang S, Andrews JP, Tadayon E, Fan JM, Garcia PA, Gonzalez-Giraldo E, Hegde M, Hullett P, Rao VR, Knowlton RC, Chang EF, Kleen JK

Mapping between fMRI and electrophysiological networks encoding depressive symptoms.

Brain stimulation

John Alvarez, Niki Sabetfakhri, Audrey Kist, Natalya Slepneva, Joline Fan, Julian Motzkin, Melanie Morrison, Leo Sugrue, Kristin Sellers, Edward Chang, Andrew Krystal, A Moses Lee

Thalamic transcranial ultrasound stimulation in treatment resistant depression.

Brain stimulation

Fan JM, Woodworth K, Murphy KR, Hinkley L, Cohen JL, Yoshimura J, Choi I, Tremblay-McGaw AG, Mergenthaler J, Good CH, Pellionisz PA, Lee AM, Di Ianni T, Sugrue LP, Krystal AD

15. Mapping Between fMRI and Electrophysiological Networks Encoding Depressive Symptoms.

Biological psychiatry

John Alvarez, Niki Sabetfakhri, Joline Fan, Natalya Slepneva, Julian Motzkin, Melanie Morrison, Leo Sugrue, Kristin Sellers, Andrew Krystal, Andrew Lee

Preprocessing Electrophysiological Data: EEG, iEEG, and MEG Data.

Statistical Methods in Epilepsy

Kristin K. Sellers, Joline M. Fan, Leighton B.N. Hinkley, Heidi E. Kirsch

Intracranial beta activity is a biomarker of circadian and stimulation-induced arousal in obsessive compulsive disorder.

Brain stimulation

Fan JM, De B, Frank AC, Basich-Pease G, Norbu T, Morrison MA, Larson P, Starr PA, Krystal AD, Lee AM

Cortical Synchrony and Information Flow during Transition from Wakefulness to Light Non-Rapid Eye Movement Sleep.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Fan JM, Kudo K, Verma P, Ranasinghe KG, Morise H, Findlay AM, Vossel K, Kirsch HE, Raj A, Krystal AD, Nagarajan SS

Closed-Loop Neurostimulation for Biomarker-Driven, Personalized Treatment of Major Depressive Disorder.

Journal of visualized experiments : JoVE

Sellers KK, Khambhati AN, Stapper N, Fan JM, Rao VR, Scangos KW, Chang EF, Krystal AD

Intracranial electrical stimulation of corticolimbic sites modulates arousal in humans.

Brain stimulation

Fan JM, Lee AM, Sellers KK, Woodworth K, Makhoul GS, Liu TX, Henderson C, Astudillo Maya DA, Martinez R, Zamanian H, Speidel BA, Khambhati AN, Rao VR, Sugrue LP, Scangos KW, Chang EF, Krystal AD

Closed-loop neurostimulation for the treatment of psychiatric disorders.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Sellers KK, Cohen JL, Khambhati AN, Fan JM, Lee AM, Chang EF, Krystal AD

46. Amygdala-Hippocampus Coherence is a Biomarker of Predominant Symptom Sets in Patients With Depression.

Biological psychiatry

Joshua Cohen, Joline M. Fan, Kristin K. Sellers, Ankit N. Khambhati, Heather E. Dawes, Katherine W. Scangos, Vikram R. Rao, Leo P. Sugrue, Philip A. Starr, Edward F. Chang, Andrew D. Krystal

468. Correspondence Between fMRI and Electrophysiological Functional Connectivity in Treatment-Resistant Depression.

Biological psychiatry

Niki Sabetfakhri, Joline Fan, Natalya Slepneva, Julian Motzkin, Melanie Morrison, Leo Sugrue, Kristin Sellers, Andrew Krystal, A Moses Lee

Epileptiform discharges triggered with direct electrical stimulation for treatment-resistant depression: Factors that modulate risk and treatment considerations.

Brain stimulation

Fan JM, Khambhati AN, Sellers KK, Stapper N, Maya DA, Kunwar E, Henderson C, Sugrue LP, Scangos KW, Chang EF, Rao VR, Krystal AD

Changes in intracranial neurophysiology associated with acute COVID-19 infection.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

Sellers KK, Stapper N, Astudillo Maya DA, Henderson C, Khambhati AN, Fan JM, Rao VR, Scangos KW, Chang EF, Krystal AD

BNST beta power is associated with diurnal variations in wakefulness and DBS-induced arousal in patients with severe OCD.

Brain stimulation

Bianca De, Joline Fan, A Moses Lee

Correspondence in network connectivity assessed using fMRI and intracranial recordings in patients with severe refractory depression.

Brain stimulation

Niki Sabetfakhri, Joline Fan, Natalya Slepneva, Julian Motkzin, Melanie Morrison, Leo Sugrue, Andrew Krystal, A Moses Lee

Modern intracranial electroencephalography for epilepsy localization with combined subdural grid and depth electrodes with low and improved hemorrhagic complication rates.

Journal of neurosurgery

Lee AT, Nichols NM, Speidel BA, Fan JM, Cajigas I, Knowlton RC, Chang EF

Network connectivity predicts effectiveness of responsive neurostimulation in focal epilepsy.

Brain communications

Fan JM, Lee AT, Kudo K, Ranasinghe KG, Morise H, Findlay AM, Kirsch HE, Chang EF, Nagarajan SS, Rao VR

Management of Status Epilepticus and Indications for Inpatient Electroencephalography Monitoring.

Neurologic clinics

Fan JM, Singhal NS, Guterman EL

Bilateral temporal lobe epilepsy: How many seizures are required in chronic ambulatory electrocorticography to estimate the laterality ratio?

Epilepsia

Chiang S, Fan JM, Rao VR

073 Whole-brain network analysis of neural oscillations during light sleep.

Sleep

Joline Fan, Kiwamu Kudo, Kamalini Ranasinghe, Hirofumi Morise, Anne Findlay, Heidi Kirsch, Andrew Krystal, Srikantan Nagarajan

Seizure Cycles in Focal Epilepsy.

JAMA neurology

Leguia MG, Andrzejak RG, Rummel C, Fan JM, Mirro EA, Tcheng TK, Rao VR, Baud MO

Evidence for long memory in focal seizure duration.

Epilepsia open

Fan JM, Chiang S, Rao VR

Data-Driven, Visual Framework for the Characterization of Aphasias Across Stroke, Post-resective, and Neurodegenerative Disorders Over Time.

Frontiers in neurology

Fan JM, Gorno-Tempini ML, Dronkers NF, Miller BL, Berger MS, Chang EF

Balancing Hemorrhage Risk with Electrode Coverage.

Neurosurgery

Anthony T Lee, Noah M.L Nichols, Benjamin Speidel, Joline Fan, Robert C Knowlton, Edward F Chang

Catastrophic stroke burden in a patient with uncontrolled psoriasis and psoriatic arthritis: a case report.

BMC neurology

Fan JM, Solomon DA, López GY, Hofmann JW, Colorado RA, Kim AS, Meisel K, Halabi C

Characterization of Multidien Rhythms in Patients with Epilepsy (S36.007).

Neurology

Joline M. Fan, Maxime O. Baud, Vikram R. Rao

Performance sustaining intracortical neural prostheses.

Journal of neural engineering

Nuyujukian P, Kao JC, Fan JM, Stavisky SD, Ryu SI, Shenoy KV

A high-performance keyboard neural prosthesis enabled by task optimization.

IEEE transactions on bio-medical engineering

Nuyujukian P, Fan JM, Kao JC, Ryu SI, Shenoy KV

Intention estimation in brain-machine interfaces.

Journal of neural engineering

Fan JM, Nuyujukian P, Kao JC, Chestek CA, Ryu SI, Shenoy KV

A high-performance neural prosthesis enabled by control algorithm design.

Nature neuroscience

Gilja V, Nuyujukian P, Chestek CA, Cunningham JP, Yu BM, Fan JM, Churchland MM, Kaufman MT, Kao JC, Ryu SI, Shenoy KV

A recurrent neural network for closed-loop intracortical brain-machine interface decoders.

Journal of neural engineering

Sussillo D, Nuyujukian P, Fan JM, Kao JC, Stavisky SD, Ryu S, Shenoy K

A brain machine interface control algorithm designed from a feedback control perspective.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

Gilja V, Nuyujukian P, Chestek CA, Cunningham JP, Yu BM, Fan JM, Ryu SI, Shenoy KV

Characterizing tumor heterogeneity with functional imaging and quantifying high-risk tumor volume for early prediction of treatment outcome: cervical cancer as a model.

International journal of radiation oncology, biology, physics

Mayr NA, Huang Z, Wang JZ, Lo SS, Fan JM, Grecula JC, Sammet S, Sammet CL, Jia G, Zhang J, Knopp MV, Yuh WT

Therapy Outcome Prediction of Cervical Cancer with the Regression Rate of Physiologic High-risk Tumor Subvolume Assessed by DCE MRI.

International Journal of Radiation Oncology • Biology • Physics

N.A. Mayr, Z. Huang, S.S. Lo, G. Jia, J.C. Grecula, J. Zhang, J.M. Fan, M.V. Knopp, W.T.C. Yuh

Long-term stability of neural prosthetic control signals from silicon cortical arrays in rhesus macaque motor cortex.

Journal of neural engineering

Chestek CA, Gilja V, Nuyujukian P, Foster JD, Fan JM, Kaufman MT, Churchland MM, Rivera-Alvidrez Z, Cunningham JP, Ryu SI, Shenoy KV

Monkey models for brain-machine interfaces: the need for maintaining diversity.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

Nuyujukian P, Fan JM, Gilja V, Kalanithi PS, Chestek CA, Shenoy KV

Quantifying Absolute Functional Risk Volume with Functional Tumor Imaging for Treatment Outcome Prediction in Cervical Cancer.

International Journal of Radiation Oncology • Biology • Physics

N.A. Mayr, J.Z. Wang, Z. Huang, S.S. Lo, J.M. Fan, J.C. Grecula, S. Sammet, C.L. Tosti, M.V. Knopp, W.T.C. Yuh